There are over 3000 medical references in the German literature showing the effectiveness and safety of ozone.  In Europe ozone has been used for 50 years by over 10,000 physicians.  In North America only a small number of Naturopathic and/or Medical doctors currently use medical ozone for treatment of disease. The mechanism of action is reported to be by immune regulation, stimulation of oxygen metabolism, improving circulation, and increasing antioxidant protection. Many conditions may benefit from Medical Ozone therapy including Lyme Disease, SEID (formerly CFS), Fibromyalgia, and autoimmune disorders.